Effect of allocryptopine on antagonizing hepatic fibrosis
- Author:
Li XIAO
1
Author Information
1. Hunan University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Allocryptopine;
CCl4;
Hepatic fibrosis;
Lipid peroxidation;
Schistosoma japomicum
- From:
Chinese Traditional and Herbal Drugs
2011;42(6):1158-1163
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the prophylactic and therapeutic effects of allocryptopine on experimental hepatic fibrosis. Methods: Experimental hepatic fibrosis models were induced by injection of tetrachloride in combination with the drinking of 5% alcohol to rats and Schistosoma japomicum infection to mice. The effects of allocryptopine anti-hepatic fibrosis were evaluated by comparing the liver and spleen indexes, tissue biochemical indices (ALT, AST), lipid peroxidation indices (GSH-Px, MDA, SOD), serum fibrosis indices (HA, PCIII LN), the expression level of Hyp and collagen type I, III (CoI, CoIII), and the liver pathology before and after allocryptopine intervention. Results: In CCl 4-induced liver fibrosis model rats, compared with model group, the liver index and the expression level of CoI were obviously decreased in allocryptopine prophylactic groups (P<0.05, 0.01), high-dose prophylactic allocryptopine could significantly reduce the expression level of CoIII (P<0.01), middle-dose prophylactic allocryptopine could obviously reduce the spleen index, the content of AST (P<0.05); in allocryptopine therapeutic group, the liver index, the content of ALT, and the expression level of CoIII were significantly decreased (P<0.05, 0.01). In S. japomicum-induced liver fibrosis model mice, prophylactic allocryptopine could reduce the content of ALT and the expression level of Hyp (P<0.05); the liver index, the contents of PCIII, HA, and ALT were significantly decreased in high-dose allocryptopine therapeutic group (P<0.05, 0.01), the liver index, the contents of PCIII, and HA were obviously decreased in middle-dose allocryptopine therapeutic group (P<0.05); In addition, the hepatic histopathology was also improved in varying degrees after allocryptopine intervention. Conclusion: Allocryptopine has certain effects on anti-injury for hepatocyte, ameliorating liver function, and prohibiting hepatic fibrosis.
