Evaluation of innovation on in vivo - In vitro correlation of gastric retenting drug delivery system for Chinese materia medica
- Author:
Zhen-Feng WU
1
Author Information
1. Key Laboratory of Modern Preparation of TCM
- Publication Type:Journal Article
- Keywords:
Artificial neural networks (ANN);
Chinese materia medica presciptions;
Gastric retenting drug delivery system (GRDDS);
In vivo-in vitro correlation (IVIVC);
Innovation
- From:
Chinese Traditional and Herbal Drugs
2011;42(6):1041-1045
- CountryChina
- Language:Chinese
-
Abstract:
The recent study on gastric retenting drug delivery system (GRDDS) used in Chinese medicinal formule has been summaried and overviewed in this paper. The key problems about the development of GRDDS have been explored, the influence about absence of the system for in vivo-in vitro correlation (IVIVC) analyzed, especially the evaluation on IVIVC model discussed, and the possible approach that artificial neural networks (ANN) are applied in GRDDS for Chinese medicinal formule has been put forward. The processing technology, evaluation of IVIVC, and the advantage, characteristic, and problems of the application of ANN have been studied in order to provide the reference for innovating research of Chinese medicinal formule.
