Extraction, isolation, and structure elucidation of two new triterpene glycosides from sea cucumber Holothuria nobilis
- Author:
Jia-Jia ZHANG
1
Author Information
1. Zhejiang Pharmaceutical College
- Publication Type:Journal Article
- Keywords:
Holothuria nobilis selenka;
Holothuriidae;
Nobiliside I;
Nobiliside II;
Triterpene glycoside
- From:
Chinese Traditional and Herbal Drugs
2011;42(8):1467-1472
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the constituents from the sea cucumber Holothuria nobilis. Methods: The compounds of the sea cucumber were separated by multi-chromatography and their structures were elucidated by physico-chemical and spectral analyses. Results: Two new triterpene glycosides were isolated and their structures have been deduced by extensive spectral analysis (IR, 2D-NMR, and ESI-MS) and chemical structures as 3-O-{3″″-O-methyl-β-D- glucopyranosyl-(1→3)-β-D-glucopyranosyl-(1→4)-β-D- quinovopyranosyl-(1→2)-4′-O-sulfate-β-D-xylopyranosyl} -holosta-22, 25-epoxy-9-ene-3β, 12α, 17α, 25β-tetraol- sodium salt (nobiliside I, 1) and 3-O-{β-D-quinovopyranosyl-(1→2) 4′-O-sulfate-β-D-xylopyranosyl}-holoshillaside 18 (16)-lactone-22, 25-epoxy-9-ene-3β, 12α, 17α-triol sodium (nobiliside II, 2). Conclusion: Two aglycons are both new compounds named nobiliside I and nobiliside II.
