Preparation and in vitro release of microcapsules for controlled release of 10-hydroxycamptothecin-loaded polylysine and alginate
- Author:
Si-Yang LI
1
Author Information
1. Alkali Soil Natural Environmental Science Center
- Publication Type:Journal Article
- Keywords:
10-hydroxycamptothecin (HCPT);
Controlled drug release;
In vitro drug release;
Layer-by-layer (LBL);
Microcapsules
- From:
Chinese Traditional and Herbal Drugs
2011;42(9):1724-1727
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To prepare microcapsules for controlled release of 10-hydroxycamptothecin (HCPT), and determine its encapsulation efficiency and drug release profile in vitro. Methods: The microcapsules loaded with HCPT were prepared using a novel coating technology based on the layer-by-layer (LBL) deposition of oppositely charged polylysine (PLL) and alginate (ALG) polyelectrolytes with good biocompatibility onto microcrystal templates. Results: The microcapsules fabricated by this method had visible core-shell structure observed by scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM); The entrapment efficiency of the microcapsules was as high as (68.41 ± 0.72)%; The release rate of HCPT decreased as the bilayers increased in vitro. Conclusion: The microcapsules of HCPT prepared by LBL have higher entrapment efficiency and are characterized with controlled drug release, which has potential for future application.
