Synthesis of diosgenin derivatives and their antithrombotic activity (II)
- Author:
Xiao-Li FU
1
Author Information
1. Tianjin Key Laboratory of Molecular Design and Drug Discovery
- Publication Type:Journal Article
- Keywords:
Antithrombotic activity;
Derivatives;
Diosgenin;
Esterification reaction;
Target compounds
- From:
Chinese Traditional and Herbal Drugs
2011;42(9):1683-1688
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To search antithrombotic substances from diosgenin derivatives by structure modification. Methods: The target compounds were synthesized by esterification reaction with diosgenin as the leading compound. Antithrombotic activity of these compounds was examined using the thrombogenesis model of arterio-veinous bypass in rats. Results: Nine compounds were prepared and their structures were confirmed by spectral methods (NMR and MS). Two compounds (Di-8 and Di-9) containing salicyl group in structure showed promising antithrombotic activity in screening experiment. Conclusion: The group of the proper active moiety in structure could improve the antithrombotic activity of diosgenin.
