Preparation of notoginseng total saponins-tanshinone composite particles by solvent deposition method and their characterization
- Author:
Ting-Ming FU
1
Author Information
1. School of Pharmacy
- Publication Type:Journal Article
- Keywords:
Characterization;
Chinese materia medica compound prescription;
Composite particle;
Notoginseng total saponins;
Tanshinone
- From:
Chinese Traditional and Herbal Drugs
2011;42(11):2216-2220
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To synchronously inhale Chinese materia medica compound using particle as inhalation drug delivery system, notoginseng total saponins-tanshinone composite particle was prepared. Methods: The composite particle of notoginseng total saponins-tanshinone was prepared by solvent deposition method and was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), differential thermal analysis (DTA), particle size analysis, and high-performance liquid chromatography (HPLC). Results: The notoginseng total saponins-tanshinone composite particle was successfully prepared by solvent deposition method, the results of characterization proved that tanshinone was coated on the notoginseng total saponins core particle. Conclusion: The preparation of composite particle provides an effective way for synchronous inhalation of Chinese materia medica compound prescription and technical support for the preparation of compound dry powder inhalations.
