Basic property of baicalin-phospholipid complex
- Author:
Ya-Jun SHI
1
Author Information
1. College of Pharmacy
- Publication Type:Journal Article
- Keywords:
1h-nmr;
Baicalin;
IR;
Phospholipid complex;
Quantum chemistry
- From:
Chinese Traditional and Herbal Drugs
2012;43(1):78-82
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the basic property of baicalin complex with phospholipid. Methods To study the baicalin complex with phospholipid by means of IR, 1H-NMR, quantum chemistry, dissolubility, and the property of permeation membrane. Results The result of IR indicated that spectrogram of baicalin complex with phospholipid had the same tendency in property with baicalin and mixture. While the peak shape and wave number of -C=O, -N-H appeared abnormal. The 1H-NMR indicated that the phospholipid complex did not produce new chemical bonds between the two molecules. But the peak shape and chemical shift produced a certain change. The quantum chemistry result revealed that the two molecules did not form new compounds. On the basis of space matching, the two formed a relatively stable spatial relation by a weaker atomic orbitaols overlap method. The solubility of baicalin was significantly improved, the permeation membrane ratio of baicalin was boost. Conclusion The formation of baicalin-phospholipid complex does not produce new chemical bonds. The two form a relatively stable complex by some weak interaction force. The physicochemical properties and biological characteristics of the complex are greatly improved.
