Chemical constituents from Dysoxylum lenticellatum
- Author:
Ting TANG
1
Author Information
1. Key Laboratory of Tropical Forest Ecology
- Publication Type:Journal Article
- From:
Chinese Traditional and Herbal Drugs
2012;43(1):38-42
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the chemical constituents from the stems of Dysoxylum lenticellatum and their cytotoxic activities. Methods Silica gel, RP-18, and Sephadex LH-20 column chromatography techniques were used for separation and purification of the compounds and extensive spectral analysis spectra were employed for structural elucidation. The cytotoxic activity was evaluated by MTT method. Results Twelve compounds were isolated from D. lenticellatum and their structures were identified as β-sitosterol (1), stigmasterol (2), 3-oxo-24, 25, 26, 27-tetranortirucall-7-ene-23(21)-lactone (3), 3α-hydroxy-24, 25, 26, 27-tetranortirucall-7-ene-23 (21)-lactone (4), laxiracemosin H (5), laxiracemosin B (6), 24, 25-epoxy-tirucall-7-ene-3, 23-dione (7), butyrospermol (8), oleanolic acid (9), taraxerone (10), taraxerol (11), and 8-hydroxy-6-methoxy-3-pentylisocoumarin (12). Conclusion All of these compounds are isolated from D. lenticellatum for the first time and the compounds 8,10-12 are reported from the plants in Dysoxylum BI. for the first time. What's more, compounds 5 and 6 are tirucallane-type alkaloids and compound 3 shows significant inhibitory activities against human cancer cell lines in vitro. Dysoxylum lenticellatum C. Y. Wu & H. Li; tirucallane-type alkaloid; 3-oxo-24, 25, 26, 27-tetranortirucall-7-ene-23(21)-lactone; laxiracemosin H; cytotoxic activity.