Anti-hepatitis virus constituents from Corydalis saxicola
- Author:
Ying-Rui WU
1
Author Information
1. Guangxi Institue of Boatny
- Publication Type:Journal Article
- Keywords:
Alkaloid;
Anti-HBV activity;
Corydalis saxicola bunting;
Dihydrochelerythrine;
Palmatine
- From:
Chinese Traditional and Herbal Drugs
2012;43(1):32-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the anti-HBV constituents from Corydalis saxola. Methods The constituents were repeatedly purified by column chromatography and were identified on the basis of spectral analysis and comparison of their spectral data with those previously reported. Compounds isolated in large amounts were assayed against HBV. Results Sixteen compounds were identified to be dihydrosanguinarine (1), d-corydaline (2), cavidine (3), stylopine (4), 6-acetonyl-5, 6-dihydrosanguinarine (5), dihydrochelerythrine (6), tetrahydropalmatine (7), adlumidine (8), (-)-salutaridine (9), palmatine (10), protopine (11), berberine (12), coptisine (13), thalifaurine (14), dehydroapocavidine (15), and (+)-magnoflorine (16). Compounds 5, 6, 8-11, 13, and 16 with high amounts were chosen to detect anti-HBV activities. Compounds 5 and 8 were moderately active, compounds 11 and 16 showed weak inhibitory effects, while compound 6 exihibited the most potent activity against HBsAg and HBeAg secretions in HepG 2.2.15 cell line, followed by compound 9. Conclusion Compounds 1, 4-6, 8, 9, 13, 14, and 16 are isolated from C. saxicola for the first time. Compound 10 is the main constituent and compound 6 exihibits the most potent activity against HBV.
