Prevention and rehabilitation of Shengxue Pills on mice injured by low-dose radiation and their mechanisms
10.7501/j.issn.0253-2670.2013.05.019
- Author:
Su-Chun YAN
1
Author Information
1. Department of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Hydroxyl radical;
Low-dose radiation;
Micronucleus rate;
Ornithine decarboxylase;
Radiation injury;
Shengxue Pills;
Superoxide anion
- From:
Chinese Traditional and Herbal Drugs
2013;44(5):595-597
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the prevention and rehabilitation of Shengxue Pills on liver, spleen, bone marrow cells, peripheral blood lymphocyte of mice injured by low-dose radiation and their mechanisms. Methods: Mice were randomly divided into five groups: control, Shengxue Pills prevention, Shengxue Pills rehabilitation, model 1 (corresponding to rehabilitation), and model 2 (corresponding to prevention) groups. Using the ELISA method to detect the activity of hydroxyl radical, superoxide anion radical, and ornithine decarboxylase (ODC) in liver and spleen cells. The bone marrow cells and peripheral lymphocyte micronucleus rate were observed under high power lens. Results: Compared with control group, the amounts of hydroxyl radical and superoxide anion radical in the two model groups were obviously increased. Compared with the corresponding model groups, the above indexes in prevention group and rehabilitation group were significantly decreased. Compared with the control group, the activity of ODC in mice of the two model groups was obviously enhanced, but bone marrow cells and peripheral lymphocyte micronucleus rate were increased. Compared with the corresponding model groups, the activity of ODC in mice of prevention and rehabilitation groups was weakened, and bone marrow cells and peripheral lymphocyte micronucleus rate were decreased. But each index of spleen cells showed no significant difference. Conclusion: Shengxue Pills could effectively prevent and rehabilitate the damage in liver cells, peripheral blood lymphocytes, and bone marrow cells of mice injured by low-dose radiation.
