Preliminary study on serum pharmacochemistry of Dahuang Fuzi Decoction
10.7501/j.issn.0253-2670.2013.05.005
- Author:
Hui GUO
1
Author Information
1. College of Pharmacy
- Publication Type:Journal Article
- Keywords:
Dahuang Fuzi Decoction;
Fingerprint;
Material basis;
Serum pharmacochemistry;
Transitional constituents to blood
- From:
Chinese Traditional and Herbal Drugs
2013;44(5):528-531
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To carry out a preliminary study on serum parmacochemistry of Dahuang Fuzi Decoction (DFD) and to research the pharmacodynamic material basis through analyzing the constituents absorbed into blood. Methods: HPLC fingerprints of DFD and serum of rats after DFD treatment were established with serum pharmacochemistry method. The serum samples collected after DFD and single crude drug treatments were compared, the constituents absorbed into the serum after DFD ig administration was determined. Results: After the rats were ig administered with DFD, 18 transitional constituents to blood were detected, among which 14 were metabolites and 4 were prototype constituents. Conclusion: After DFD treatment, the constituents absorbed into blood are mainly from Rhei Radix et Rhizoma and Aconiti Lateralis Radix Praeparata, and the serum pharmacochemistry signs could provide the evidence for the further research of the material basis of the decoction.
