In vivo absorptive dynamics of arctiin in intestine of rats
10.7501/j.issn.0253-2670.2013.06.018
- Author:
Chen-Wen LI
1
Author Information
1. Department of Pharmacy
- Publication Type:Journal Article
- Keywords:
Absorption in intestine;
Arctiin;
Dymamic characteristic;
In vivo intestinal perfusion;
Passive transport
- From:
Chinese Traditional and Herbal Drugs
2013;44(6):727-730
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the in vivo absorptive characteristic of arctiin in small intestine of rats. Methods: The intestine absorption model of arctiin was established by in vivo intestinal perfusion method. The absorption rate constants (Ka), absorption half time (t1/2), absorption percent of per unit of time (P), and apparent permeability coefficient (Papp) were calculated and compared to investigate the absorptive dynamics of arctiin in intestine of rats. Results: At the concentration range of 10-50 μg/mL, Ka, t1/2, P, and Papp showed no significant difference, and had no connection with concentration of arctiin. Conclusion: Arctiin complies with the first-order absorptive kinetics and the absorptive mechanism in intestine may be passive transport.
