Preparation technology of matrine self-microemulsifying drugs
10.7501/j.issn.0253-2670.2013.04.008
- Author:
Hong-Song LI
1
Author Information
1. School of Pharmacy
- Publication Type:Journal Article
- Keywords:
HPLC;
Matrine;
O/W type microemulsion;
Pseudoternary phase diagram;
Self-microemulsifying
- From:
Chinese Traditional and Herbal Drugs
2013;44(4):414-419
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To develop the matrine self-microemulsifying drug delivery system (SMEDDS) and evaluate its quality. Methods: The solubility test and pseudoternary phase diagram were utilized to select proper matrine microemulsions prescription. On this basis, matrine-SMEDDS was formulated and HPLC method was used to determine the drug content in matrine-SMEDDS; The appearance, morphology, particle size, particle size distribution, Zeta potential, drug loading, and stability of matrine in the liposome were studied. Results: The best prescription of matrine-SMEDDS was matrine-oleic-ethyloleate-EL-40-isopropanol (0.5:0.15:0.15:0.35:0.35). The selected matrine-SMEDDS was transparent liquid with good liquidity and stability and could form O/W type microemulsion with water, with an average particle size of (68.00 ± 0.07) nm (n = 3). The average drug loading was 42.689 mg/mL (n = 3). Conclusion: The preparation technology is simple and stable, and provides a strong foundation for research of matrine-SMEDDS.
