Chemical constituents from Glechoma longituba
10.7501/j.issn.0253-2670.2013.04.003
- Author:
Qiu-Fang ZHU
1
Author Information
1. Institute of Pharmaceutical Informatics
- Publication Type:Journal Article
- Keywords:
(+)-lariciresinol;
(-)-syringaresinol;
Anti-oxidant activity;
Dihydrocaffeic acid;
Glechoma longituba (Nakai) Kupr.
- From:
Chinese Traditional and Herbal Drugs
2013;44(4):387-390
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents from Glechoma longituba and their anti-oxidant activity in vitro. Methods: The chemical constituents were isolated and purified by solvent extraction, repeated silica gel column chromatography, and reverse phase preparative HPLC. Their structures were identified on the basis of ESI-MS and NMR spectra. The anti-oxidant activities of these compounds were screened by DPPH free radical scavenging assay in vitro. Results: Ten compounds were isolated and elucidated as cosmosiin (1), dihydrocaffeic acid (2), caffeic acid (3), isololiolide (4), vomifoliol (5), glecholone (6), apigenin (7), aurantiamide (8), (+)-lariciresinol (9), and (-)-syringaresinol (10). Conclusion: Compounds 2, 4, and 8-10 are isolated from the plants in Glechoma L. for the first time; Compounds 9 and 10 are lignans firstly obtained from this plant. DPPH free radical scavenging assays show that compounds 2, 3, 9, and 10 exhibit potential anti-oxidant activity.