Study on tripterin sustained-release dropping pills
10.7501/j.issn.0253-2670.2013.07.012
- Author:
Hai-Jian XIA
1
Author Information
1. Affiliated Hospital on Integration of Chinese and Western Medicine
- Publication Type:Journal Article
- Keywords:
In vitro release;
Preparation technology;
Roundness;
Solid dispersion;
Sustained-release dropping pills;
Tripterin
- From:
Chinese Traditional and Herbal Drugs
2013;44(7):834-838
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To prepare the Tripterin Sustained-release Dropping Pills (TSRDPs), investigate the disperse state and in vitro release, and optimize the preparation technology. Methods: The TSRDPs were prepared by solid dispersion method with PEG 4000 and glycerol monostearate (GM) as carrier materials. Orthogonal design was conducted to explore the influencing factors of the preparation technology by evaluating the indexes of roundness and weight difference. Results: The ideal condition of TSRDPs: the ratio of tripterin-GM-PEG 4000 was 1:3:7; the temperature of drug mixture was 80 °C; dropping speed was 20 d/min; dropping distance was 5 cm; and the condensate temperature was 15 °C. Tripterin existed as amorphous state in carriers. The maximum cumulative release amount of tripterin was 91.2% at 12 h. Conclusion: The prepared TSRDPs have a good sustained-release effect.
