Optimization of matrix recipe of Compound Analgesic Cataplasm by central composite design-response surface method
10.7501/j.issn.0253-2670.2013.08.013
- Author:
Hong-Bing ZHANG
1
Author Information
1. Tianjin University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Central composite design;
Compound Analgesic Cataplasm;
Matrix recipe;
Response surface method;
Single factor test
- From:
Chinese Traditional and Herbal Drugs
2013;44(8):985-988
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the matrix recipe of Compound Analgesic Cataplasm. Methods: Taking the early adhesion and appearance (paste traits, residue, and skin adhesive ability) as evaluation indexes, the optimal matrix recipe of Compound Analgesic Cataplasm was optimized by single factor test and central composite design-response surface method, and the optimal preparation process was determined at the same time. Results: The optimal ratio of the matrix is as follows: NP-700-carbopol 940-aluminium glycinate-silica-glycerin (5.34:0.63:0.2:6:30). Conclusion: The optimal matrix has the moderate adhesion without residue but with better paste traits and skin adhesive ability under the ideal preparation technology.
