Research on preparation technology of baicalein particles by supercritical CO2 antisolvent method
10.7501/j.issn.0253-2670.2013.08.010
- Author:
Juan HUANG
1
Author Information
1. School of Pharmacy
- Publication Type:Journal Article
- Keywords:
Antisolvent method;
Baicalein;
Microparticle;
Supercritical CO2;
Volume average particle size
- From:
Chinese Traditional and Herbal Drugs
2013;44(8):970-973
- CountryChina
- Language:Chinese
-
Abstract:
Objective: The preparation technology of baicalein microparticles was optimized with volume average particle size (VAPS) of micropaticles as the evaluation index. Methods: The baicalein micropartocles were prepared by supercritical CO2 antisolvent method. On the basis of single factor tests, orthogonal design was used to optimize the preparation process of baicalein microparticles. The microparticle size distribution, scanning electron microscopy (SEM) analysis, infrared spectrum (IR), and differential scanning calorimetry (DSC) were used to analyze the microparticles. Results: The suitable conditions optimized by orthogonal test were set as follows: solvent flow rate 0.75 mL/min, pressure 8 MPa, temperature 48 °C, and mass concentration of baicalein 4 mg/mL. Under the optimum conditions, the VAPS of the prepared microparticles was obviously smaller than that of the baicalein. And the shapes of baicalein in prepared microparticles were irregular under SEMA. IR and DSC analyses showed that the chemical structure of baicalein microparticles was not changed while the thermodynamic properties of baicalein might change. Meanwhile, the purity of baicalein became higher after the treatment. Conclusion: Supercritical CO2 antisolvent method is feasible to prepare baicalein microparticles and provides a reference basis for preparing microparticles at the same time.
