Optimization of molding technology for Compound Yizhihao Dropping Pills by Box-Behnken central composite design
10.7501/j.issn.0253-2670.2013.09.013
- Author:
Wen JIANG
1
Author Information
1. School of Pharmacy
- Publication Type:Journal Article
- Keywords:
Box-Behnken central composite design;
Compound Yizhihao Dropping Pills;
Dissolution rate;
Molding technology;
Response surface methodology
- From:
Chinese Traditional and Herbal Drugs
2013;44(9):1134-1140
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the molding technology for Compound Yizhihao Dropping Pills. Methods: Box-Behnken central composite design was adopted; The matrix ratio, the ratio of extract to matrix, and dropping speed were taken as the independent variables; The weight variation of pills and general normalized value were taken as dependent variables. The response surface methodology (RSM) was used to estimate the relationship between the dependent and independent variables and to validate the optimal formulation. Then the differences of dissolution behaviors between the granule and dropping pills were investigated by in vitro dissolution test. Results: The optimized conditions were as follows: the ratio of PEG 4000 to PEG 6000 was 3.8:1, the ratio of extracts to matrix was 1:2.5, the dropping speed was 28 drops/min. Under these conditions, the measured value was consistent with the predicated value with RSD < 5%. The dissolution rates of dropping pills was significantly higher than those of the granule. Conclusion: The molding technology of dropping pills is optimized, which is simple and feasible.
