Effect and safety of Maren Soft Capsule on constipation
10.7501/j.issn.0253-2670.2013.12.024
- Author:
Dong-Bing LI
1
Author Information
1. Xiyuan Hospital of Chinese Medicine Academy of Sciences
- Publication Type:Journal Article
- Keywords:
Colon mucous membrane melanosis;
Constipation;
Low-dose effect;
Maren Soft Capsule;
Side effect
- From:
Chinese Traditional and Herbal Drugs
2013;44(12):1645-1647
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effect of low-dose Maren Soft Capsule (MSC) on constipation and colonic mucosa. Methods: Patients (208 cases) with colon slow transit constipation and mixed constipation were divided into treatment and control groups. MSC (two pills, once daily) and Sennae Folium (5 g) were given to the patients in the treatment and control groups, respectively, for 10 months. The recovery rate, total significant efficiency, and total efficiency were determined by defecation frequency and gastrointestinal transmission experiment. The side effects such as bloating and abdominal pain were observed. Results: The recovery rate in the treatment group was lower than that in the control group, and the total significant efficiency and total efficiency were similar to those in the control group. There was no colon melanosis in the treatment group after 10 month, while 26.9% of the patients in the control group were observed with colon melanosis. Conclusion: The low-dose MSC has the therapeutic effect on constipation with high safety.
