Effect of Tongxi Powder on blood uric acid of mice with acute hyperuricemia
10.7501/j.issn.0253-2670.2013.12.021
- Author:
Hong-Xia YANG
1
Author Information
1. Huzhou Food and Drug Administrator Institute
- Publication Type:Journal Article
- Keywords:
Acute hyperuricemia;
Allopurinol;
Blood uric acid;
Gout;
Tongxi Powder
- From:
Chinese Traditional and Herbal Drugs
2013;44(12):1635-1637
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of Tongxi Powder (TP) on decreasing the uric acid of mice with acute hyperuricemia. Methods: The mice were divided into model, allopurinol (positive control, 10 mg/kg), low-, mid-, and high-dose (100, 300, and 500 mg/kg) TP groups. Except the model group, mice in other groups were administered once daily for 3 d. The acute hyperuricemia model of mice was established 2 h after the last administration and then ip uric acid (450 mg/kg), and the blood uric acid contents were determined after 80 min. Results: Compared with the model group, TP at mid-and high-dose could obviously decrease the blood uric acid level in mice (P < 0.01), so did allopurinol (P < 0.01). The effect of high-dose TP group was the same as that of allopurinol group. Conclusion: TP could inhibit the increase of blood uric acid in mice with acute hyperuricemia.
