Chemical constituents from Coreopsis lanceolata and their bioactivities
10.7501/j.issn.0253-2670.2013.12.007
- Author:
Dong-Xu SHAO
1
Author Information
1. College of Science and Engineering
- Publication Type:Journal Article
- Keywords:
3, 4-dihydroxy-benzaldehyde;
Coreopsis lanceolata L.;
Friedeline;
P-hydroxy cinamic acid;
Sesquiterpenes
- From:
Chinese Traditional and Herbal Drugs
2013;44(12):1558-1561
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents in the whole herb of Coreopsis lanceolata and to investigate the antibacterial activity. Methods: The compounds in the whole herb of C. lanceolata were isolated and purified by column chromatography and identified based on spectral analyses (MS, NMR). The antibacterial activities of compounds 1-8 were screened. Results: Fifteen compounds including eight sesquiterpenes were isolated from the chloroform fraction in the whole herb of C. lanceolata and were identified as 1β, 5α-diangeloyloxy-eudesm-(15)-ene (1), 1β, 6α-dihydroxyeudesm-4(15)-ene (2), 10α-hydroxyoplopan-4-one (3), (7R*)-opposit-4(15)-ene-1β, 7-diol (4), (7R*)-opposit-4(15)-ene-1β, 8-diol (5), (7R*)-opposit-4(15)-ene-1β, 11-diol (6), (7R*)-opposit-4(15)-ene-1β, 7α-diol (7), 4(15)-eudesmene-1β, 7α-diol (8), p-hydroxy cinamic acid (9), 3-methoxy4-hydroxy-benzoic acid (10), methyl-p-hydroxybenzoate (11), 3, 4-dihydroxy-benzaldehyde (12), β-sitosterol (13), friedeline (14), and friedelinol (15). Conclusion: Compounds 1-15 are obtained from the whole herb of C. lanceolata for the first time. The bioassays show that the compounds 3 and 4 have the stronger inhibition against Staphylococcus aureus.
