Preparation of paeoniflorin microcapsule and its in vitro release behavior
10.7501/j.issn.0253-2670.2013.13.011
- Author:
Zi-Liang DONG
1
Author Information
1. Key Laboratory of Standardization of Chinese Herbal Medicines of Ministry of Education
- Publication Type:Journal Article
- Keywords:
Complex agglutination method;
Doehlert design;
In vitro release;
Microcapsule;
Paeoniflorin
- From:
Chinese Traditional and Herbal Drugs
2013;44(13):1756-1760
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the preparation technology of paeoniflorin microcapsule (PM), and to study its behavior of in vitro release. Methods: Using encapsulation efficiency and drug loading as indicators, the PM were prepared by complex agglutination method, the preparation technology of PM was optimized by Doehlert design. The dissolution volume of PM within 20 h and the release curve were measured by HPLC, afterwards its morphology and particle size were studied by electron microscopy. Results: The encapsulation efficiency and drug loading were significantly related to the ratio of coating material, stirring speed, and pH value. The optimal conditions were as follows: the ratio of coating material to paeoniflorin was 4.3:1, the stirring speed was 305 r/min, and the pH value was 4.0. The obtained microcapsules were smooth round capsule-shaped, with non-adhesions and uniform particle size, the encapsulation efficiency was up to 83.81%, the drug loading was 24.24%, and the microcapsule diameter was below 200 μm, with sustained-release effect. Conclusion: The complex agglutination method is simple and reliable to prepare PM, and the product is stable. As a new formulation, microcapsule has a broad prospect for development.
