Chemical constituents from Scolopendra multidens (I)
10.7501/j.issn.0253-2670.2013.13.005
- Author:
Yin-Dan FU
1
Author Information
1. College of Chinese Materia Medica
- Publication Type:Journal Article
- Keywords:
7, 8-dimethyl-isoalloxazine;
Cyclo-(L-Phe-L-Tyr);
Indole-3-acetamide;
Scolopendra multidens Newport;
Uracil
- From:
Chinese Traditional and Herbal Drugs
2013;44(13):1726-1729
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents from Scolopendra multidens. Methods: Compounds were isolated and purified by a combination of chromatographic techniques including silica gel, ODS, Sephadex LH-20 column chromatography, middle and low pressure preparative chromatograms, and pre-HPLC. The structures were elucidated on the basis of physicochemical properties and spectroscopic analyses. Results: Ten compounds were separated and identified as uracil (1), 7, 8-dimethyl-isoalloxazine (2), indole-3-acetamide (3), N-(2-phenylethyl) acetamide (4), (3S)-1, 2, 3, 4-tetrahydro-β-carboline-3-carboxylic acid (5), cyclo-(L-Ile-L-Pro) (6), cyclo-(L-Leu-L-Pro) (7), cyclo-(L-Phe-L-Pro) (8), cyclo-(L-Phe-L-Tyr) (9), and cyclo-(L-Val-L-Pro) (10). Conclusion: All the compounds are isolated from S. multidens for the first time.
