In vivo pharmacokinetics of curcumin-phospholipid complex-chitosan microspheres in rats
10.7501/j.issn.0253-2670.2013.14.014
- Author:
Qin TANG
1
Author Information
1. The Engineering and Technology Center of Efficacy Evaluation
- Publication Type:Journal Article
- Keywords:
Chitosan microspheres;
Curcumin;
Pharmacokinetics;
Phospholipid complex;
Phospholipid complex-chitosan microspheres
- From:
Chinese Traditional and Herbal Drugs
2013;44(14):1939-1943
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare the in vivo pharmacokinetics of curcumin-phospholipid complex-chitosan microspheres (Cur-PLC-CM), Cur-PLC, Cur-CM, and crude drug of Cur, and to discuss the advantage of PLC-CM as carrier. Methods: SD rats were ig administered with the above four preparations 100 mg/kg (corresponding to Cur), respectively. Then blood samples were obtained at certain time points. The concentration of Cur in blood was analyzed by HPLC method using emodin as internal standard. The mobile phase was acetonitrile-2% acetic acid (55:45). Concentration-time curve was drawn and the data were analyzed by DAS program. Results: The tmax and t1/2 of Cur-PLC-CM were 2.0 and 3.2 h, respectively, which were much longer than those of crude drug (0.6 and 1.2 h), Cur-CM (1.4 and 2.3 h), and Cur-PLC (1.2 and 1.7 h). The AUC of Cur-PLC-CM was 7.49, 2.07, and 2.67 times as those of crude drug, Cur-CM, and Cur-PLC. Conclusion: The PLC-CM have better sustained-releasing and absorption property than CM and PLC, which may have a great potential to be used as oral delivery system for the low solubility and short half-life drug.
