Study on chemical constituents from Corydalis Rhizoma in Pan'an
10.7501/j.issn.0253-2670.2013.16.002
- Author:
Xin-Bao YANG
1
Author Information
1. Beijing University of Chinese Medicines
- Publication Type:Journal Article
- Keywords:
(-)-corypalmine;
8-trichloromethyl-7, 8-dihydrocoptisine;
Berberine;
Corydalis Rhizoma;
Didehydroglaucine
- From:
Chinese Traditional and Herbal Drugs
2013;44(16):2200-2207
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents from Corydalis Rhizoma in Pan'an county as characteristically regional traditional Chinese medicinal materials. Methods: The constituents were separated and purified by chromatography on silica gel and Sephadex LH-20 columns, as well as the chemical structures of alkaloids were determined by physicochemical properties and spectral data analyses. Results: Twenty alkaloids were obtained and identified as tetrahydrocoptisine (1), tetrahydrocolumbamine (2), tetrahydropalmatine (3), corybulbine (4), isocorybulbine (5), 8-trichloromethyl-7, 8-dihydrocoptisine (6), corydaline (7), 8-oxocoptisine (8), (-)-corypalmine (9), dehydrocorydaline (10), 13-methylpalmatrubine (11), oxoglaucine (12), protopine (13), noroxyhydrastinine (14), tetrahydroberberine (15), didehydroglaucine (16), pontevedrine (17), coptisine (18), palmatine (19), and berberine (20). Conclusion: Compounds 6, 9, and 16 are isolated from Corydalis Rhizoma for the first time. All 13C-NMR and 1H-NMR data of compounds 6 and 16 are assigned for the first time using 2D NMR.
