Comparison on pharmacodynamic differences between Simiao Pill with crude Atractylodis Rhizoma and bran stir-baked Atractylodis Rhizoma
10.7501/j.issn.0253-2670.2013.18.017
- Author:
Zhong-Xu BAI
1
Author Information
1. College of Pharmacy
- Publication Type:Journal Article
- Keywords:
Adjuvant arthritis;
Bran-baked Atractylodis Rhizoma;
Crude Atractylodis Rhizoma;
Pharmacodynamics;
Simiao Pills
- From:
Chinese Traditional and Herbal Drugs
2013;44(18):2577-2580
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the pharmacodynamic differences between Simiao Pills with crude Atractylodis Rhizoma and bran stir-baked Atractylodis Rhizoma on the treatment of adjuvant arthritis. Methods: Wistar rats were randomly divided into blank control group (normal saline), model control group (normal saline), Tripterygium wilfordii glycosides (TWG) group (9.45 mg/kg), low-and high-dose (1.080 and 4.320 g/kg) Simiao Pills (crude Atractylodis Rhizoma) group, low-and high-dose (1.080 and 4.320 g/kg) Simiao Pills (stir-baked Atractylodis Rhizoma with bran) group. Except the blank control group, the other groups were modeled to adjuvant arthritis with complete Freund's. Paw edema value, spleen and thoracic gland indexes, serum interleukin-1β (IL-1β), and nitric oxide (NO) were observed. Results: Both Simiao Pills with crude Atractylodis Rhizoma and bran stir-baked Atractylodis Rhizoma could inhibit paw edema, decrease spleen index, advance the thoracic gland index, and decrease IL-1β and NO. The Simiao Pills with crude Atractylodis Rhizoma showed better effects. Conclusion: Both Simiao Pills with crude Atractylodis Rhizoma and bran stir-baked Atractylodis Rhizoma show a certain therapeutic effect on adjuvant arthritis, but the crude Atractylodis Rhizoma is in favor of the efficacy of Simiao Pills.
