Technological optimization and quality evaluation of Xinjianwei Tablet
10.7501/j.issn.0253-2670.2013.18.012
- Author:
Yun-Xia LI
1
Author Information
1. Jingfukang Pharmaceutical Group Co. Ltd.
- Publication Type:Journal Article
- Keywords:
Hesperidin;
HPLC;
Preparation process optimization;
Quantitative determination;
Xinjianwei Tablet
- From:
Chinese Traditional and Herbal Drugs
2013;44(18):2551-2555
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the preparation for Xinjianwei Tablet, and to establish a method for the quantitative determination of hesperidin. Methods: The new process used dried tangerine peel raw powder as medicine to replace the traditional water decocting process. The effect of the new process was verified with the content of hesperidin as evaluation index. Results: The new process is superior to the traditional one on the premise of the basic substances and the total yield did not change basically. RP-HPLC was used to determine hesperidin and the linearity was good in the range of 10.1-202.5 μg/mL, r = 0.9999. The average recovery was 98.37% with RSD = 1.0%. Conclusion: The improved process is more rational and simple, and the method based on HPLC is simple, reliable, and reproducible. It could be used effectively for the quality control of Xinjianwei Tablet.
