Adsorption studies on plastic packaging materials of Shuangbai Film Spraying Agent
10.7501/j.issn.0253-2670.2013.18.009
- Author:
Si-Jian OU
1
Author Information
1. New Drug Research and Development Center
- Publication Type:Journal Article
- Keywords:
Adsorption;
Anthraquinone;
Compatibility test;
Polyethylene terephthalate;
Shuangbai Film Spraying Agent
- From:
Chinese Traditional and Herbal Drugs
2013;44(18):2537-2541
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the components adsorbability of Shuangbai Film Spraying Agent (SFSA) packaged by three types of plastic medicinal materials, and to optimize the packaging material for SFSA. Methods: SFSA was dispensed in polyethylene terephthalate (PET), polypropylene (PP), and high density polyethylene (HDPE) plastic spraying bottles and the factors influencing test and conventional sample test were carried out. The characteristics of sample solution and spraying bottles and the internal color of spraying bottles were inspected, the optimal packaging material was screened for compatibility long-term test, the wall color changes of spraying bottles were observed, and the contents of drug concentration and the bottle wall adsorption were determined by HPLC. Results: The degree of change in color after six months of the three types of drug packaging material was HDPE > PP > PET; The hardness and impact strength of PP bottle decreased. PET bottles only adsorbed small quantities of aloe-emodin, rhein, emodin, chrysophanol, emodin, and none of the other ingredients. The chrysophanol and emodin were unstable in the aqueous solution, and the contents of other indicator components of SFSA in the PET bottle were stable. Conclusion: PET is suitable to be the packaging materials of SFSA.
