Comparative study on absorption of Luodian Borneolum and muscone after nasal unidirectional perfusion with different Xingnaojing preparations in rats
10.7501/j.issn.0253-2670.2013.20.019
- Author:
Ran WEN
1
Author Information
1. School of Chinese Pharmacy
- Publication Type:Journal Article
- Keywords:
Luodian Borneolum;
Muscone;
Nasal absorption;
Nasal unidirectional perfusion;
Xingnaojing Microemulsion;
Xingnaojing Nasal Drop
- From:
Chinese Traditional and Herbal Drugs
2013;44(20):2894-2897
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare the absorption characteristics of Luodian Borneolum and muscone after nasal unidirectional perfusion with different Xingnaojing preparations in rats. Methods: The nasal unidirectional perfusion model was used, the contents of Luodian Borneolum and muscone were determined by GC method, and the absorption of Luodian Borneolum and muscone in Xingnaojing Nasal Drop (XN) and Xingnaojing Microemulsion (XM) were compared. Results: The absorption rate constants (Ka) of Luodian Borneolum in XN and XM were (1.00 ± 0.02)and (0.76 ± 0.03) min-1, respectively, and the Ka values of muscone in XN and XM were (0.76 ± 0.02) and (0.58 ± 0.10) min-1, respectively. Conclusion: The absorption of Luodian Borneolum and muscone in XN are both faster than that in XM.
