Study on prescription technology of Compound Zhizi Gel
10.7501/j.issn.0253-2670.2013.21.008
- Author:
Li-Ming WEI
1
Author Information
1. College of Pharmacy
- Publication Type:Journal Article
- Keywords:
Azone;
Compound Zhizi Gel;
Ferulic acid;
Geniposide;
Paeonol;
Transdermal diffusion
- From:
Chinese Traditional and Herbal Drugs
2013;44(21):2982-2987
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the prescription of Compound Zhizi Gel (CZG) and to optimize the prescription technology of CZG. Methods: Orthogonal test, cold-resistant and heat-resistant tests were used to optimize the prescription technology. Using spreadability, glossiness, evenness, centrifugal stability, and in vitro transdermal diffusion as indexes, other excipients of prescription were optimized. Results: The optimal CZG prescription was Carbopol 940-glycerin-propylene glycol-triethanolamine-azone (1.5%:1.5%:3%:5%:5%). Conclusion: The optimized prescription is reliable and stable. It could meet the production requirements of CZG.
