Effect of monotetrahydrofuran annonaceous acetogenins on mitochondrial complex I of rats
10.7501/j.issn.0253-2670.2013.23.020
- Author:
Yun-Jie MIAO
1
Author Information
1. Nanjing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Core configurations;
Hepatic mitochondrial;
Mitochondrial complex I;
Monotetrahydrofuran annonaceous acetogenins;
Structure-activity relationship
- From:
Chinese Traditional and Herbal Drugs
2013;44(23):3368-3371
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the activity of mono-tetrahydrofuran (THF) annonaceous acetogenins (ACGs) against mitochondrial complex I of rats. Methods: The inhibitory activity of mono-THF ACGs with six different chemical structures against mitochondrial complex I of rats was investigated to clarify the carbon number and substituted hydroxyl number between THF ring and lactone ring as well as the effect of the core configuration in THF ring on mitochondrial complex I of rats. Results: The results show that mono-THF ACGs can inhibit the mitochondrial complex I of rats. With analysis of the results from the structure-activity relationship between antitumoral activity and their chemical structure of mono-THF ACGs, the less the carbon number between the two rings is, the better their inhibitory activities are; The number of substituted hydroxyl groups is not the decisive factor for influencing its activity in mono-THF ACGs. Conclusion: The inhibitory activity of compound's configurations with th/t/er is better than that of the compound's configurations with th/t/th in mono-THF ACGs.
