Lipase-catalyzed synthesis of cholesteryl vinyl hemi-sebacate for selective targeting of liposomes in organic media
10.7501/j.issn.0253-2670.2013.23.007
- Author:
Hua NIE
1
Author Information
1. College of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Asialoglycoprotein receptor;
Candida rugosa Lipase;
Cholesterol;
Cholesteryl vinyl hemi-sebacate;
Lipase-catalyzed
- From:
Chinese Traditional and Herbal Drugs
2013;44(23):3289-3295
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To synthesize cholesteryl vinyl hemi-sebacate from cholesterol and divinyl sebacate in non aqueous phase. Methods: TLC, MS, and NMR were used to identify the structure of production; the technological conditions of enzymatic esterification were determined through orthogonal test. Results: The best condition: isooctane 5 mL, reaction temperature 35°C, reaction time 24 h, Candida rugosa Lipase 10 mg/mL, molar ratio of cholesterol to divinyl sebacate 1:6. Conclusion: The highest esterification rate is above 95%.
