Effects of compatible herbs and pH value conditions on change rule of anthraquinones in Rhei Radix et Rhizoma
10.7501/j.issn.0253-2670.2013.24.009
- Author:
Zhen XIE
1
Author Information
1. College of Pharmacy
- Publication Type:Journal Article
- Keywords:
Aconiti Lateralis Radix Praeparata;
Anthraquinones;
Aurantii Fructus Immaturus;
Coptidis Rhizoma;
Drug pair compatibility;
Magnoliae Officinalis Cortex;
Moutan Cortex;
PH value;
Rhei Radix et Rhizoma;
Scutellariae Radix;
Vinegar Kansui Radix
- From:
Chinese Traditional and Herbal Drugs
2013;44(24):3476-3481
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effects of various compatible herbs and pH value conditions on the change rule of anthraquinones in Rhei Radix et Rhizoma (RRR). Methods: The pH value of the extracted solution from seven compatible herbs[vinegar Kansui Radix (vKR), Moutan Cortex (MC), Scutellariae Radix (SR), Coptidis Rhizoma (CR), Aconiti Lateralis Radix Praeparata (ALRP), Aurantii Fructus Immaturus (AFI), and Magnoliae Officinalis Cortex (MOC)] were determined, then RRR was added into hydrochloric acid solution with the same pH value as the above solutions and boiled, in which the contents of anthraquinones were determined by UV-Vis and HPLC. The contents of anthraquinones were compared with those in the decoction of compatible herbs and single RRR. Results: The results of UV-Vis showed that total anthraquinones got the lowest amount when RRR and CR were boiled together while the highest appeared when RRR and SR were boiled together; the contents of total anthraquinones were increased when the pH value was increased. The results of HPLC showed that the five anthraquinones got the lowest dissolving-out quantity when RRR and CR were boiled together while the highest appeared when RRR and ALRP were boiled together. Under the conditions of different pH values, the highest dissolving-out quantity was got when the pH value reached 5.6. Conclusion: Both the compatible herbs and pH value could affect the dissolution of anthraquinones during the extraction. However, the effects of various compatible herbs and different pH value conditions adjusted by hydrochloric acid are different, and the pH value conditions have greater effects.
