Research progress on neuroprotective mechanism of epigallocatechin-3-gallate against cardiovascular and cerebrovascular ischemia-reperfusion injury
10.7501/j.issn.0253-2670.2014.18.029
- Author:
Miao-Miao WANG
1
Author Information
1. Department of Pharmacology, Medical College, Shandong University
- Publication Type:Journal Article
- Keywords:
Anti-inflammation;
Anti-oxidation;
Cardiovascular and cerebrovascular;
Epigallocatechin-3-gallate;
Ischemic reperfusion injury
- From:
Chinese Traditional and Herbal Drugs
2014;45(18):2732-2736
- CountryChina
- Language:Chinese
-
Abstract:
Epigallocatechin-3-gallate (EGCG) is one of the major components in green tea. It has been studied that EGCG possesses anti-oxidative, anticancer, anti-inflammatory, and antibacterial effects. In recent years, cardiovascular and cerebrovascular diseases have been exerting the most significant impact on human health, however, only a few neuroprotective drugs can be used in the treatment of ischemic stroke. Many studies reveal that EGCG has unique therapeutic effect on cardiovascular and cerebrovascular ischemia-reperfusion injury. EGCG mainly exerts its protective effects by regulating oxidative stress, anti-apopsis, anti-inflammation, activation of adenosine receptors, lowering blood-brain barrier permeability, and reducing matrix metalloproteinase-9 expression. This review focuses on the mechanism of action of EGCG in the treatment of cardiovascular and cerebrovascular ischemia-reperfusion injury, in order to provide rationale or the development of effective drugs for ischemic cardiovascular and cerebrovascular diseases.
