Genetic analysis of ovarian microcystic stromal tumor.
10.5468/ogs.2016.59.2.157
- Author:
Jae Hoon LEE
1
;
Hyun Soo KIM
;
Nam Hoon CHO
;
Jung Yun LEE
;
Sunghoon KIM
;
Sang Wun KIM
;
Young Tae KIM
;
Eun Ji NAM
Author Information
1. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Women's Cancer Clinic, Yonsei Cancer Center, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul, Korea. nahmej6@yuhs.ac
- Publication Type:Case Report
- Keywords:
CTNNB1 mutation;
Microcystic stromal tumor;
Ovary;
Pyrosequencing
- MeSH:
Exons;
Female;
Hyalin;
Ovary;
Vimentin;
Wilms Tumor
- From:Obstetrics & Gynecology Science
2016;59(2):157-162
- CountryRepublic of Korea
- Language:English
-
Abstract:
Microcystic stromal tumor (MCST) of the ovary is a rare subtype of ovarian tumor first described in 2009. Although high nuclear expression of β-catenin and β-catenin gene (CTNNB1) mutation are related with ovarian MCST, the origin and genetic background of ovarian MCST remain unclear. In this study, two cases of ovarian MCST are presented. Microscopically, the tumors showed a microcystic pattern and regions with lobulated cellular masses with intervening hyalinized, fibrous stroma. Tumor cells of both cases were stained with CD10, vimentin, and Wilms tumor 1. Genetic analysis was performed and β-catenin gene (CTNNB1) mutation in exon 3 was detected in both cases. This is the first report in regards of detecting CTNNB1 mutation in ovarian MCST through the use of pyrosequencing (a novel sequencing technique).
