Systemic Amyloid Protein a Amyloidosis Involving the Heart in a Patient with Rheumatoid Arthritis.
- Author:
Ji Won HWANG
1
;
Eun Seok JEON
;
Jung Min HA
;
Woo Joo LEE
;
Eun KIM
;
Sehyo YUNE
Author Information
1. Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Systemic amyloid protein A amyloidosis (AA amyloidosis);
Congestive heart failure;
Rheumatic arthritis
- MeSH:
Amyloid*;
Amyloidosis*;
Arthritis, Rheumatoid*;
Biopsy;
Dyspnea;
Echocardiography;
Heart Failure;
Heart*;
Humans;
Kidney;
Renal Insufficiency, Chronic;
Rheumatic Fever;
Skin;
Staphylococcal Protein A*
- From:Korean Journal of Medicine
2014;86(6):739-743
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Amyloidosis can be identified by the deposition of amyloid fibrils in biopsy specimens from multiple organs, including the heart, kidney, skin, and bowel. Systemic amyloid protein A amyloidosis (AA amyloidosis) is commonly associated with chronic inflammatory diseases or chronic infectious conditions. Cardiac involvement in AA amyloidosis is found in < 1% of reported cases. Here, we report a case of cardiac AA amyloidosis confirmed by heart biopsy in a 54-year-old-female with a medical history of rheumatoid arthritis and stage 4 chronic kidney disease due to renal amyloidosis. She had suffered from progressive aggravation of dyspnea for 2 years. Infiltrative disease involving the heart was suspected by echocardiography, and the patient was diagnosed with AA amyloidosis involving the heart by cardiac biopsy. This is a rare case of cardiac involvement in a patient with systemic AA amyloidosis associated with rheumatoid arthritis.
