Comparative studies on anti-inflammatory and analgesic activities of different fractions from Isatidis Radix
10.7501/j.issn.0253-2670.2014.17.017
- Author:
Yi-Min MA
1
Author Information
1. Jiangsu Kanion Parmaceutical Co., Ltd.
- Publication Type:Journal Article
- Keywords:
Analgesia;
Anti-inflammation;
Isatidis Radix;
PGE2;
TNF-α
- From:
Chinese Traditional and Herbal Drugs
2014;45(17):2517-2521
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the anti-inflammatory and analgesic activities of the different fractions from Isatidis Radix. Methods: The anti-inflammatory effects were observed by a in vitro model of LPS-stimulated RAW264.7 macrophages, and the analgesic effects were evaluated by the writhing test and the tail-immersion test in mice. Results: The water extract, 30%, 50%, and 70% ethanol extracts of Isatidis Radix all had anti-inflammatory and analgesic activities. The 50% and 70% ethanol extracts were the main anti-inflammatory effective fractions. The water extract and 70% ethanol extract were the main analgesic effective fractions. Conclusion: Different fractions of Isatidis Radix all have anti-inflammatory and analgesic activities, and the 70% ethanol extract has stronger activities. The mechanism of the anti-inflammatory and analgesic activities of the 70% ethanol extract may be related to the inhibition of the release of TNF-α and PGE2 from macrophages.
