In vivo metabolic pathway of liquiritin in rats
10.7501/j.issn.0253-2670.2014.17.014
- Author:
Shi-Qi DONG
1
Author Information
1. Yantai University
- Publication Type:Journal Article
- Keywords:
HPLC-QTRAP-MS;
Liquiritin;
Metabolic pathway;
Metabolites;
Peak area normalization method
- From:
Chinese Traditional and Herbal Drugs
2014;45(17):2499-2505
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the in vivo metabolic pathways of liquiritin (LQ) in rats. Methods: An HPLC-QTRAP-MS method was established and applied to identify the metabolites of LQ in bile, urine, feces, and plasma after ig administration of LQ (300 mg/kg) to rats. Results: A total of nine metabolites were found in rats. The major metabolic pathway of LQ was deglucosidation to liquiritigenin (LG) and dehydration, glucuronidation, and sulfation of LG. Conclusion: LQ undergoes extensive phases I and II metabolism in rats. The major metabolites of LQ are LG and its glucuronides and sulfates.
