Hodgkin's Lymphoma after Autologous Hematopoietic Stem Cell Transplantation for Angioimmunoblastic T-cell Lymphoma.
- Author:
Su Youn PARK
1
;
Hyung Min YU
;
Jiwan KIM
;
Sang Hee AN
;
Wook Youn KIM
;
Mina HUR
;
Hong Gi LEE
Author Information
1. Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea. mlee@kuh.ac.kr
- Publication Type:Case Report
- Keywords:
Lymphoproliferative disorder;
Hodgkin disease;
Hematopoietic stem cell transplantation;
Epstein-Barr virus
- MeSH:
Adult;
Biopsy;
Chills;
Drug Therapy;
Fever;
Hematopoietic Stem Cell Transplantation*;
Herpesvirus 4, Human;
Hodgkin Disease*;
Humans;
Incidence;
Korea;
Lymphoma, T-Cell*;
Lymphoproliferative Disorders;
Peripheral Blood Stem Cell Transplantation;
Plasma;
T-Lymphocytes
- From:Korean Journal of Medicine
2014;86(6):774-780
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Post-transplantation lymphoproliferative disorder (PTLD) is a serious complication that can develop after either solid organ or hematopoietic stem cell transplantation (HSCT). The incidence of Hodgkin's lymphoma (HL) ranges from 0.5-1.0% of PTLD after HSCT without T-cell depletion. Here, we report a case of HL-PTLD that occurred after autologous peripheral blood stem cell transplantation for an angioimmunoblastic T-cell lymphoma (AITL). A 36-year-old patient developed fever and chills with multiple lymphadenopathies at day 673 after auto-HSCT for AITL. Three months after the transplant, the patient developed fever with elevated plasma Epstein-Barr virus (EBV)-PCR values. The excisional biopsy revealed HL at Ann Arbor stage IIIB. A total of 8 cycles of chemotherapy with ABVD please define were performed, and the patient has remained disease-free. To our knowledge, this is first case report of HL-PTLD after auto-PBSCT in Korea.
