Formulation optimization of Kyllinga brevifolia total flavonols solid dispersion controlled porosity osmotic pump tablets
10.7501/j.issn.0253-2670.2014.19.010
- Author:
Cai-Xia SUN
1
Author Information
1. Chengdu University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Controlled porosity osmotic pump tablets;
In vitro drug release;
Kyllinga brevifolia total flavonols;
Orthogonal design;
Solid dispersion
- From:
Chinese Traditional and Herbal Drugs
2014;45(19):2782-2786
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To prepare Kyllinga brevifolia total flavonols (KBTF) solid dispersion controlled porosity osmotic pump tablets, and investigate the effects of core tablets and coating on its in vitro drug release behavior, so as to optimize the formulation. Methods: Using KBTF solid dispersion prepared by solvent method as drug core to increase the dissolution of KBTF in vitro, the optimal forrmulation of KBTF solid dispersion controlled porosity osmotic pump tablets was selected via the single factor investigation and orthogonal design. Results: The optimal formula was as follows: osmotic promoter was sodium chloride 100 mg, content of PEG 400 was 150%, content of DBP was 20%, and rate of weight growth of coating membrane was 2%. Conclusion: KBTF solid dispersion controlled porosity osmotic pump tablets with optimal forrmulation can stably release drugs in 12 h and the accumulative drug release rate was more than 90%, whilst its in vitro drug release behavior was up to the character of zero-order drug release.
