Chemical constituents from whole herb of Lagochilus platyacanthus
10.7501/j.issn.0253-2670.2014.22.003
- Author:
Cheng-Gang ZHANG
1
Author Information
1. The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
(+)-isolarisiresinol;
Acacetin;
Diosmetin;
Lagochilus platyacanthus Rupr.;
Luteolin-7, 4'-dimethyl ether
- From:
Chinese Traditional and Herbal Drugs
2014;45(22):3224-3229
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents from the whole herb of Lagochilus platyacanthus. Methods: The chemical constituents were isolated and purified by various chromatographic techniques and the structures were identified by spectral analysis. Results: Twenty-one compounds were isolated from the 95% ethanol extract of L. platyacanthus, including 15 flavonoids: apigenin-7, 4'-dimehyl ether (1), acacetin (2), apigenin (3), luteolin-7, 3', 4'-trimethyl ether (4), luteolin-7, 4'-dimethyl ether (5), diosmetin (6), chrysoeriol (7), quercetin-3-O-rutinoside-7-O-glucoside (8), rutin (9), horridin (10), apigenin-6, 8-di-C-β-D-glucopyranoside (11), isorhamnetin-3-O-rutinoside (12), isorhamnetin-3-O-robinobioside (13), isorhamnetin-3-O-β-D-glucoside (14), and isorhamnetin-3-O- rutinoside-4'-O-glucoside (15); three lignans: 1-(4-hydroxy-3-methoxy)-phenyl-2-[4-(1, 2, 3-trihydroxypropyl)-2-methoxy]-phenoxy- 1, 3-propandiol (16), (+)-isolarisiresinol 3-α-O-β-D-glucopyranoside (17), and (-)-isolarisiresinol 3-α-O-β-D-glucopyranoside (18); two iridoids: 8-O-acetylharpagide (19) and geniposidic acid (20), and one phenylethanoid glycoside: lavandulifolioside (21). Conclusion: All the compounds are obtained from this plant for the first time. The compounds are isolated from the plants in genus Lagochilus Bunge for the first time except compounds 1, 3, 9, 19, and 20.
