Preparation and characterization of micronized trans-cinnamic acid by anti-solvent crystallization method
10.7501/j.issn.0253-2670.2014.15.009
- Author:
Xiu-Hua ZHAO
1
Author Information
1. Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University
- Publication Type:Journal Article
- Keywords:
Anti-solvent method;
Antioxidation;
Bioavailability;
Dissolution;
Trans-cinnamic acid;
Ultrafine;
Univariate analysis
- From:
Chinese Traditional and Herbal Drugs
2014;45(15):2165-2171
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Using ethanol as solvent, deionized water as anti-solvent, and HPMC as the surfactant, to prepare trans-cinnamic acid (TCA) micro powder by single factor analysis. The effects of five experimental parameters on the mean particle size (MPS) and morphology of TCA nanosuspension were investigated. Methods: Transmission electron microscope (TEM), laser granulometric analysis, Fourier transform infrared spectroscopy (FTIR), high performance liquid chromatography-mass spectrometry (LC-MS), X-ray diffraction (XRD), differential scanning calorimetry (DSC), and dissolution were used to analyze the characteristic of micronized TCA nanosuspension. Results: The micronized TCA with an MPS of 130 nm was obtained under the optimum conditions. The dissolution rate of TCA nanosuspension was 1.67 times of raw drug. Conclusion: Using anti-solvent recrystallization to prepare micronized TCA can improve the solubility and dispersion of TCA nanosuspension in water, and they provide the basis for further formulation development.
