Chemical constituents from effective fraction of leaves of Microcos paniculata with protection on acute myocardial ischemia injury
10.7501/j.issn.0253-2670.2014.23.003
- Author:
Kun-Ping LI
1
Author Information
1. Department of Pharmacy, Guangdong Pharmaceutical University
- Publication Type:Journal Article
- Keywords:
5, 6, 7, 8, 4'-pentamethoxyflavone;
Acute myocardial ischemia;
Caffeic acid;
Erucicamide;
Leaves of Microcos paniculata;
Vitexin
- From:
Chinese Traditional and Herbal Drugs
2014;45(23):3373-3376
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents from the effective fraction of the leaves of Microcos paniculata, which can protect acute myocardial ischemia injury induced by isoprenaline. Methods: The chemical constituents were isolated and purified by combined using chromatography on silica gel, and Sephadex LH-20 column, and preparative HPLC. The structures of the isolated compounds were elucidated by NMR and MS spectral data. Results: Eleven compounds were isolated from the effectively protective fraction with the protection on acute myocardial ischemia injury and identified as vitexin (1), isovitexin (2), isorhamnetin (3), kaempferol (4), quercetin (5), 5, 6, 7, 8, 4'-pentamethoxyflavone (6), nobiletin (7), vanillic acid (8), caffeic acid (9), ferulic acid (10), and erucicamide (11). Conclusion: Compounds 6, 7, 9 and 11 are isolated from the plants in Microcos Linn. for the first time. Compound 11 is the firstly reported fatty acid amide and compounds 6 and 7 are the firstly reported polymethoxylated flavonoids with the obvious anti-inflammatory activity in this genus.
