Preparation of lyophilized powder of oral Pueraria flavonoids nanosuspension and determination of dissolution rates of its four effective components
- Author:
Zhi-Ping WANG
1
Author Information
1. School of Pharmacy, Guangdong Pharmaceutical University
- Publication Type:Journal Article
- Keywords:
3'-hydroxypuerarin;
Daidzein;
Daidzin;
Dissolution rate;
Effective components;
Lyophilized powder;
Nanosuspension;
Pueraria flavonoids;
Puerarin
- From:
Chinese Traditional and Herbal Drugs
2014;45(5):635-641
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To prepare the lyophilized powder of Pueraria flavonoids nanosuspension (PF-NS) and to determine the dissolution rates of its four effective components (3'-hydroxypuerarin, puerarin, daidzin, and daidzein). Methods: PF-NS was prepared by the high pressure homogenization (HPH) technology. The lyophilized formula contained mannitol as lyoprotectant. The dissolution rates of the four effective components from lyophilized powder of PF-NS as well as the physical mixture were determined, with artificial gastric juice (pH 1.2) as dissolvent. Results: The optimal lyophilized powder of PF-NS was loosed with the particle size of (479.7 ± 14.7) nm, polydisperse index of 0.524 ± 0.220, and Zeta potential of (29.68 ± 3.97) mV, respectively. The in vitro accumulated dissolution rate of lyophilized powder of PF-NS was higher than that of the physical mixture. Conclusion: The method employed to prepare the lyophilized powder in PF-NS is simple and feasible. The lyophilized powder of PF-NS could improve the in vitro dissolution rate notablely. It might be a novel vehicle potentially for nano-drug delivery system of PF.
