Study on balanced release of Chuanping extract sustained-release tablets combined with different accessories
10.7501/j.issn.0253-2670.2014.06.006
- Author:
Yan-Qu CAI
1
Author Information
1. Institute of Chinese Materia Medica Development, Guangdong Pharmacological University
- Publication Type:Journal Article
- Keywords:
Balanced release;
Chuanping;
Complex components;
Improvement of traditional sustained-release accessories;
Modern sustained-release accessories
- From:
Chinese Traditional and Herbal Drugs
2014;45(6):774-777
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the balanced release of complex components of Chuanping extract sustained-release tablets combined with different accessories. Methods: With methamphetamine, pseudoephedrine, and scopolamine as indexes, HPLC and the in vitro release test were applied to determining the accumulated release rate of the complex components in nine sustained-release Chuanping extract preparations (Q1-Q9), and to evaluating the influences of different accessories to the release behaviors of complex components in vitro. Results: The differences about dissolutions of four single modern materials in Chuanping extract sustained-release tablets Q1-Q3 were significant, and Q4 released fast. All of them were not balanced release. The differences about dissolutions of single improved Chinese materia medica (CMM) sustained-release accessories made Chuanping extract sustained-release tablets Q5 were significant, and Q6 was balanced release. The difference about dissolutions of complex improved CMM sustained release excipients made Chuanping extract sustained-release tablets Q9 was incomplete, the balanced release of Q8 was not well. The balanced-release of complex components of Q7 was well. Conclusion: Different accessories would affect the balanced release of sustained-released Chuanping extract tablet in vitro. The modern sustained-release accessories are hard to achieve the balanced release of complex components of CMM compound sustained-release preparations, but the improved traditional sustained-release accessories could be achieved well.
