Chemical constituents from Toona ciliata var. henryi and their anti-inflammatory activities
10.7501/j.issn.0253-2670.2014.06.002
- Author:
Feng ZHANG
1
Author Information
1. College of Pharmacy, Henan University
- Publication Type:Journal Article
- Keywords:
Anti-inflammation;
Toona ciliata Roem. var. henryi (C. DC.) C. Y. Wu;
Toonaciliatin J;
β-daucositerol;
β-sitosterol
- From:
Chinese Traditional and Herbal Drugs
2014;45(6):755-759
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents from Toona ciliata var. henryi and their bioactivities. Methods: Column chromatography on silica gel, RP-C18, and Sephadex LH-20 columns was used to separate and purify the chemical constituents. The structures were elucidated by physicochemical properties and spectroscopic analyses. These compounds were isolated and evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells. Results: Fifteen compounds were isolated from the stem barks of T. ciliata var. henryi and identified as odoratone (1), toonaciliatin F (2), toonaciliatin G (3), toonaciliatin J (4), hispidone (5), bourjotinolone A (6), 3-episapeline A (7), piscidinol A (8), aglaiodiol (9), toonaciliatin M (10), 2α, 19-dihydroxy-9-epi-ent-pimara-7, 15-diene (11), cleomiscosin B (12), cleomiscosin C (13), β-sitosterol (14), and β-daucositerol (15). The IC50 values of compounds 4 and 10 were (11.0 ± 0.7) and (28.8 ± 2.7) μmol/L. Conclusion: All the compounds are isolated from this plant for the first time. Compounds 11-13 are yielded from the plants of Toona Roem. for the first time. Compounds 4 and 10 show the moderate inhibitory activities.
