Chemical constituents of Solidago virgaurea and their anti-inflammatory activities
10.7501/j.issn.0253-2670.2014.06.001
- Author:
Tao LI
1
Author Information
1. University of Jinan, Shandong Academy of Medical Sciences, Key Laboratory of Rare and Uncommon Diseases of Shandong Province
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory activity;
P-hydroxybenzoic acid;
Solidago virgaurea glycoside;
Solidago virgaurea L.;
Solidagobenzofuran
- From:
Chinese Traditional and Herbal Drugs
2014;45(6):749-754
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents of Solidago virgaurea and their pharmacological activities. Methods: The compounds were isolated and purified from the plant with chromatography techniques and the chemical structures were identified on the basis of spectrascopic analyses and physicochemical properties, and the anti-inflammatory effects of obtained benzyl benzoate compounds were evaluated by ELISA. Results: Nine compounds were isolated from 90% ethanol extract of S. virgaurea and their structures were identified as 2'-methoxybenzyl-2-methoxy-6-hydroxybenzoate (1), 2'-methoxybenzyl-2, 6-dimethoxybenzoate (2), solidagobenzofuran (3), hexadecanoic acid (4), salicylic acid (5), p-hydroxybenzoic acid (6), solidago virgaurea glycoside (7), kaempferol-3-O-β-D-rutinoside (8), and rutin (9). Conclusion: Compounds 3 and 7 are new compounds; Compounds 4 and 6 are obtained from the plants of Solidago L. for the first time; Compounds 1 and 2 are isolated from this species for the first time. Anti-inflammatory studies show that compounds 1 and 2 could inhibit the TNF-α and IL-6 release of LPS-induced RAW264.7 murine monocytes, while compound 7 shows no significant inhibitory effect.
