Evaluation of fluidized granulation technology of Jianwei Xiaoshi Tablet by multicriteria synthesizing grading method
10.7501/j.issn.0253-2670.2014.07.010
- Author:
Guo-Chao YUE
1
Author Information
1. Key Laboratory for Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Fluidized granulation;
Jianwei Xiaoshi Tablet;
Multicriteria synthesizing grading method;
Orthogonal design;
Technology optimization
- From:
Chinese Traditional and Herbal Drugs
2014;45(7):949-954
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the feasibility of multicriteria synthesizing grading method using in the optimization of the fluidized granulation technology for Jianwei Xiaoshi Tablet (JXT), and to provide a reference for fluidized granulation technology to spread and apply in the pelletization of materials with strong stickiness. Methods: Using orthogonal design, the property parameters of granule and tablet were measured, and the best process parameters were optimized. Results: The optimal process parameters were as follows: The inlet air temperature was 55°C, the inlet pressure was 8 kPa, the spray pressure was 30 kPa, and the flow rate of the liquid was 1.0-2.5 mL/min. Conclusion: The multicriteria synthesizing grading method used in optimizing the fluidized granulation technology of JXT is stable and feasible, and provides theory evidence for improving the productivity and product quality.
