Chemical constituents from roots tubers of Serratula chinensis
10.7501/j.issn.0253-2670.2014.07.003
- Author:
Hai-Jiao TANG
1
Author Information
1. Department of Natural Medicinal Chemistry, College of Chinese Materia Medica, China Pharmaceutical University
- Publication Type:Journal Article
- Keywords:
20-hydroxyecdysone;
20-hydroxyecdysone 2-O-β-D-glucopyranoside;
20-hydroxyecdysone-20, 22-monoacetonide;
Roots tubers of Serratula chinensis;
Serratula L.
- From:
Chinese Traditional and Herbal Drugs
2014;45(7):906-912
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the chemical constituents from the roots tubers of Serratula chinensis. Methods: The chemical constituents were separated and purified by silica gel, Sephadex LH-20, ODS column chromatographies, and preparative HPLC. Their structures were determined by physicochemical properties and spectral data. Results: Sixteen compounds (ecdysteroids) were isolated from the n-butanol fraction of 95% ethanol extract in the root tubers of S. chinensis, and their structures were identified as 20-hydroxyecdysone (1), polypodine B (2), carthamosterone (3), 20-hydroxyecdysone-20, 22-monoacetonide (4), 24-epi-abutasterone (5), polypodine C (6), coronatasterone (7), 20-hydroxyecdysone 2-O-β-D-glucopyranoside (8), 20-hydroxyecdysone 25-O-β-D-glucopyranoside (9), polypodine B 20, 22-acetonide (10), shidasterone (11), 2-O-acetyl-20-hydroxyecdysone (12), 3-O-acetyl-20-hydroxyecdysone (13), 20-hyderoxyecdysone-20, 22-butylidene acetal (14), 24-methylene-shidasterone (15), and ajugasterone D (16). Conclusion: Compounds 2, 4, 5, 7-10, 12, 15, and 16 are isolated from this plant for the first time, and compounds 5, 7-10, and 16 are found in the plants of genus Serratula L. for the first time.
