Effect of Jimaitong Tablet on blood pressure and related active substances of rats with long-term drinking
10.7501/j.issn.0253-2670.2014.09.015
- Author:
Su-Hong CHEN
1
Author Information
1. Wenzhou Medical University
- Publication Type:Journal Article
- Keywords:
Hypertension;
Jimaitong Tablet;
Liver function;
Renin-angiotensin-aldosterone system;
Thromboxane
- From:
Chinese Traditional and Herbal Drugs
2014;45(9):1278-1283
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effects of Jimaitong Tablet on the blood pressure, liver and kidney function, and vasoactive substances of the rats with long-term drinking. Methods: Forty SD rats were divided into four groups including control, model, Jimaitong Tablet, and Amlodipine groups (n = 10). The rats drinking spirits freely, and the alcohol concentration increased in gradient. After 4 weeks of modeling, the rats were ig administered successively for 49 weeks, once daily. The blood pressure (such as SBP, DBP, and MBP) and blood biochemical markers of liver and kidney function (such as ALT, AST, Cr, and UA) had been regularly monitored. After the last administration, the rat blood was collected from the inferior vena cava plexus, and the angiotensin II (AngII), aldosterone (ALD), and thromboxane B2 (TXB2) levels in plasma were measured. Results: The blood pressure (SBP, DBP, and MBP) of rats increased after 12-week continuous drinking and was stable until week 53. After the administration of Jimaitong Tablet for 15 weeks onwards, the blood pressure (SBP, DBP and MBP) of rats with long-term drinking could be significantly reduced. It showed stable antihypertensive effect during the administration for up to 49 weeks (P < 0.01, 0.05). Jimaitong Tablet could improve ALT and AST levels in serum to varying degrees (P < 0.01, 0.05) at the administration of 38-48 weeks. Jimaitong Tablet could reduce ALD, AngII, and TXB2 levels (P < 0.01, 0.05) in plasma of the model rats during the administration of 49 weeks. Conclusion: Jimaitong Tablet has good effect on hypertensive rats induced by long-term drinking, and has a distinct improving effect on liver injury in rats. Its mechanism of the antihypertensive effect may be related to the renin-angiotensin-aldosterone system and thromboxane level.
